The story is set during the Ming dynasty. Female police officer Yuan Jin Xia (Tan Song Yun) receives the order to help the fierce embroidered uniform guard (imperial secret police) Lu Yi (Allen Ren) solve a case in Yangzhou. The two can’t seem to get along at first, but through the hardships they have to endure together, they learn to rely on each other. When they finally become lovers, however, the ill-fated story of their families is brought to light.
The drama tells the story of Ye Chong (Allen Ren), a secret agent of the Communist Party who goes by the name “Autumn Cicada”. In 1941, he poses as a Japanese officer stationed in Hong Kong to stop the conspiracy of the Japanese while trying to accomplish a top secret mission he has been given.
Inspired by a legendary folk tale, The Destiny of White Snake tells a heart-wrenching love story between an immortal and a human. She is Bai Yao Yao (Yang Zi), a white snake roaming the mortal realm when she meets Xu Xuan (Allen Ren), the master of the medicinal valley. There is a also second couple pairing between Xiao Qing (Li Man), a green snake whose fate becomes intertwined with a demon catcher named Qi Xiao (Mao Zi Jun).